Guest Post | Advt. | Query: info@techrecur.com

HKBU develops world-first metal-based probes for detection of dopamine receptors, a cancer biomarker


Discovery can be potentially developed as a novel early cancer detection technology.

HONG KONG, May 16, 2018 – (ACN Newswire) – A team led by Dr Edmond Ma Dik-lung, Associate Professor of the Department of Chemistry of Hong Kong Baptist University (HKBU) has developed the world’s first iridium(III)-based probes for imaging dopamine receptors in living cells. The discovery has enhanced the understanding of dopamine receptors in carcinogenesis, and the findings can be potentially developed as a novel early cancer detection technology. The study was published in the inside front cover of Chemical Science, the flagship journal of the Royal Society of Chemistry.

Dopamine is an important neurotransmitter in the central nervous system of the human body and plays important roles in motivation, cognition and motor control. While dopamine receptors have long been implicated in neurodegenerative diseases, such as Parkinson’s disease, recent evidence has linked dopamine receptors also with various cancers, including lung, breast and colon cancers. Traditional detection methods for dopamine receptors include the enzyme-linked immunosorbent assay (ELISA). However, such methods suffer from high cost, incompatibility with living systems, and are not suitable for the real-time study of the biological role of dopamine receptors.

The metal-based probes developed by the team are able to selectively bind to dopamine receptors on lung cancer cells, “lighting up” the cells and making them visible to the naked eye. The probes enable the monitoring and tracking of dopamine receptors in living cells in a real-time and in a non-invasive fashion. Moreover, the experiment results demonstrated that the imaging colour intensity was correlates with the expression levels of dopamine receptors on cancer cells. These probes could therefore both help to elucidate the role of dopamine receptors in the pathogenesis of cancers and offer a potential diagnostic tool for the early screening of cancers. Importantly, the metal-based probes avoid the problems of poor photostability and photobleaching that limit conventional fluorescent imaging dyes.

The research project entitled “Cell imaging of dopamine receptor using agonist labeling iridium(III) complex” was led by Dr Edmond Ma of HKBU together with Professor Leung Chung-hang of the Institute of Chinese Medical Sciences, University of Macau. Other collaborators of the project included researchers from the School of Chinese Medicine of HKBU, the City University of Hong Kong, University of Florida, USA, and Hunan University, China.

Dr Ma said, “Early detection is crucial for improving the survival rate of hard-to-treat cancers such as lung cancer, which is associated with dopamine receptor expression. For instance, data from the American Cancer Society shows that patients with early stage non-small cell lung cancer (NSCLC) have a five-year survival rate of about 92%, but this drops to only about 36% when the cancer has progressed to an advanced stage. We therefore believe that these dopamine receptor probes show great promise for the development of molecular diagnostic tools for the early detection of cancer.”

Dr Ma added that because the probes could successfully track the internalisation process of dopamine receptors in cells, they also represent powerful tools for studying the role of dopamine receptors in the pathogenesis of cancer.

Media enquiries:
Tina Ng of the Communication and Public Relations Office (+852 3411 5262) or Dr Edmond Ma of the Department of Chemistry (+852 3411 7075)

Have any Question or Comment?

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

…… ……. … …

……… …. …….

….. …… ………

……. ….. …….

.. ……. …….. 0

buy! buy! CHEAP! Telefonie VoIP CHEAP! buy! buy! CHEAP!

.. ……. …….. .

buy! buy! CHEAP! Telefonie VoIP CHEAP! buy! buy! CHEAP!

Categories

……. ….. ……..

——————————————–

For the 2012 MLB period, we found an totals forecast Joao’s Renowned Over/Under João Zorro Gonçalves, Zcode Totals Pro, System of the time with progressions that have been successful over 98 98% ... We eventually perfected our over/under program ( Zcodesystemexclusive ), although it h-AS has brought years of investigation. Five Steps to Making a Winning MLB Method: 1. Execute appropriate cash management tools. 2. MLB rules that are comprehend. 3.Extensive testing back to make sure successful longterm results ...

——————————————–

There is always a challenge when you're dealing with the Foreign Exchange Market. That's just the nature of the beast. The best thing you can do is to learn about how the market operates as a whole so that you will be ready to meet these challenges. iq option penipu Never be misled by any profit gains in binary options. This is the number-one way traders end up losing their money and ultimately failing. Remember that the same things that make you laugh can make you cry in this market, and you can lose that $700.

——————————————–

Learning Polish has never been this fun and easy as with our podcasts Learn Polish with Polishpod101 Start today and become conversational in Polish in no time

——————————————–

The Best Website Agen Poker Resmi www.sakupoker.com Terpercaya come join

——————————————–

Do you need edmonton phone systems service ? Call complete communications today!

……… ……… .

——————————————–

High-tech solutions for easy start-up of your IPTV/OTT-business

——————————————–

——————————————–

If you want to purchase not only one item, you have a chance to enjoy privileges. There is a sale’ tab on the site which offers a fantastic range of reduced counterfeit watches and accessories, such as sunglasses, cufflinks, watch straps and pens. Luxury Jewelry Replica At MCA.MN On Sale You get a 5% discount if you buy two pieces, this discount increases to 10% if you buy 4 pieces or more. There is free international shipping on all orders on this site. We also offer customers a free return anytime with a 100% money back guarantee.

Archives

——————————————–